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NADPH oxidase 4-derived superoxide mediates flow-stimulated NKCC2 activity in thick ascending limbs
Luminal flow augments Na(+) reabsorption in the thick ascending limb more than can be explained by increased ion delivery. This segment reabsorbs 30% of the filtered load of Na(+), playing a key role in its homeostasis. Whether flow elevations enhance Na(+)-K(+)-2Cl(−) cotransporter (NKCC2) activity...
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| Publicado no: | Am J Physiol Renal Physiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6031920/ https://ncbi.nlm.nih.gov/pubmed/29672130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00631.2017 |
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