Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers

To optimally penetrate biological hydrogels such as mucus and the tumor interstitial matrix, nanoparticles (NPs) require physicochemical properties that would typically preclude cellular uptake, resulting in inefficient drug delivery. Here, we demonstrate that (poly(lactic-co-glycolic acid) (PLGA) c...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Yu, Miaorong, Xu, Lu, Tian, Falin, Su, Qian, Zheng, Nan, Yang, Yiwei, Wang, Jiuling, Wang, Aohua, Zhu, Chunliu, Guo, Shiyan, Zhang, XinXin, Gan, Yong, Shi, Xinghua, Gao, Huajian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031689/
https://ncbi.nlm.nih.gov/pubmed/29973592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05061-3
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