CDK6 antagonizes p53-induced responses during tumorigenesis

Tumor formation is a multi-step process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a stage-specific manner. In early stages CDK6 kinase induces a com...

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Bibliografiset tiedot
Julkaisussa:Cancer Discov
Päätekijät: Bellutti, Florian, Tigan, Anca-Sarmiza, Nebenfuehr, Sofie, Dolezal, Marlies, Zojer, Markus, Grausenburger, Reinhard, Hartenberger, Svenja, Kollmann, Sebastian, Doma, Eszter, Prchal-Murphy, Michaela, Uras, Iris Z., Höllein, Alexander, Neuberg, Donna S., Ebert, Benjamin L., Ringler, Anna, Mueller, Andre C., Loizou, Joanna I., Hinds, Philip W., Vogl, Claus, Heller, Gerwin, Kubicek, Stefan, Zuber, Johannes, Malumbres, Marcos, Farlik, Matthias, Villunger, Andreas, Kollmann, Karoline, Sexl, Veronika
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031305/
https://ncbi.nlm.nih.gov/pubmed/29899063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0912
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