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Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning
In both yeast and mammals, the topoisomerase poison camptothecin (CPT) induces fork reversal, which has been proposed to stabilize replication forks, thus providing time for the repair of CPT‐induced lesions and supporting replication restart. We show that Tel1, the Saccharomyces cerevisiae ortholog...
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| Published in: | EMBO Rep |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley and Sons Inc.
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6030699/ https://ncbi.nlm.nih.gov/pubmed/29739811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745535 |
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