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Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
Farnesoid-X-Receptor (FXR) plays a central role in maintaining bile acid (BA) homeostasis by transcriptional control of numerous enterohepatic genes, including intestinal FGF19, a hormone that strongly represses hepatic BA synthesis. How activation of the FGF19 receptor at the membrane is transmitte...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6030054/ https://ncbi.nlm.nih.gov/pubmed/29968724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04697-5 |
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