αO-Conotoxin GeXIVA Disulfide Bond Isomers Exhibit Differential Sensitivity for Various Nicotinic Acetylcholine Receptors but Retain Potency and Selectivity for the Human α9α10 Subtype

Nicotinic acetylcholine receptor (nAChR) subtypes exhibit distinct neuropharmacological properties that are involved in a range of neuropathological conditions, including pain, addiction, epilepsy, autism, schizophrenia, Tourette’s syndrome, Alzheimer’s and Parkinson’s diseases, as well as many type...

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Publicado en:Neuropharmacology
Main Authors: Zhangsun, Dongting, Zhu, Xiaopeng, Kaas, Quentin, Wu, Yong, Craik, David J., McIntosh, J. Michael, Luo, Sulan
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029978/
https://ncbi.nlm.nih.gov/pubmed/28416445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.04.015
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