Cx43 Overexpression in Osteocytes Prevents Osteocyte Apoptosis and Preserves Cortical Bone Quality in Aging Mice

Young, skeletally mature mice lacking Cx43 in osteocytes exhibit increased osteocyte apoptosis and decreased bone strength, resembling the phenotype of old mice. Further, the expression of Cx43 in bone decreases with age, suggesting a contribution of reduced Cx43 levels to the age‐related changes in...

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Detalhes bibliográficos
Publicado no:JBMR Plus
Principais autores: Davis, Hannah M, Aref, Mohammad W, Aguilar‐Perez, Alexandra, Pacheco‐Costa, Rafael, Allen, Kimberly, Valdez, Sinai, Herrera, Carmen, Atkinson, Emily G, Mohammad, Arwa, Lopez, David, Harris, Marie A, Harris, Stephen E, Allen, Matthew, Bellido, Teresita, Plotkin, Lilian I
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029870/
https://ncbi.nlm.nih.gov/pubmed/29978155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10035
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