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Connexin 43 Is Required for the Anti-Apoptotic Effect of Bisphosphonates on Osteocytes and Osteoblasts In Vivo

Connexin (Cx)43 is required for inhibition of osteocyte and osteoblast apoptosis by bisphosphonates in vitro. Herein, we evaluated its requirement for the in vivo actions of bisphosphonates using mice in which Cx43 was deleted specifically from osteocytes and osteoblasts (Cx43(ΔOb−Ot/−) mice). Effec...

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Bibliografiske detaljer
Main Authors: Plotkin, Lilian I, Lezcano, Virginia, Thostenson, Jeff, Weinstein, Robert S, Manolagas, Stavros C, Bellido, Teresita
Format: Artigo
Sprog:Inglês
Udgivet: Amer Soc Bone & Mineral Res. 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648607/
https://ncbi.nlm.nih.gov/pubmed/18597631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.080617
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