Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging

Skeletal aging results in apoptosis of osteocytes, cells embedded in bone that control the generation/function of bone forming and resorbing cells. Aging also decreases connexin43 (Cx43) expression in bone; and osteocytic Cx43 deletion partially mimics the skeletal phenotype of old mice. Particularl...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Aging Cell
Päätekijät: Davis, Hannah M., Pacheco‐Costa, Rafael, Atkinson, Emily G., Brun, Lucas R., Gortazar, Arancha R., Harris, Julia, Hiasa, Masahiro, Bolarinwa, Surajudeen A., Yoneda, Toshiyuki, Ivan, Mircea, Bruzzaniti, Angela, Bellido, Teresita, Plotkin, Lilian I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2017
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418188/
https://ncbi.nlm.nih.gov/pubmed/28317237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12586
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