Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging

Skeletal aging results in apoptosis of osteocytes, cells embedded in bone that control the generation/function of bone forming and resorbing cells. Aging also decreases connexin43 (Cx43) expression in bone; and osteocytic Cx43 deletion partially mimics the skeletal phenotype of old mice. Particularl...

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Pubblicato in:Aging Cell
Autori principali: Davis, Hannah M., Pacheco‐Costa, Rafael, Atkinson, Emily G., Brun, Lucas R., Gortazar, Arancha R., Harris, Julia, Hiasa, Masahiro, Bolarinwa, Surajudeen A., Yoneda, Toshiyuki, Ivan, Mircea, Bruzzaniti, Angela, Bellido, Teresita, Plotkin, Lilian I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418188/
https://ncbi.nlm.nih.gov/pubmed/28317237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12586
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