Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging

Skeletal aging results in apoptosis of osteocytes, cells embedded in bone that control the generation/function of bone forming and resorbing cells. Aging also decreases connexin43 (Cx43) expression in bone; and osteocytic Cx43 deletion partially mimics the skeletal phenotype of old mice. Particularl...

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Bibliografiska uppgifter
I publikationen:Aging Cell
Huvudupphovsmän: Davis, Hannah M., Pacheco‐Costa, Rafael, Atkinson, Emily G., Brun, Lucas R., Gortazar, Arancha R., Harris, Julia, Hiasa, Masahiro, Bolarinwa, Surajudeen A., Yoneda, Toshiyuki, Ivan, Mircea, Bruzzaniti, Angela, Bellido, Teresita, Plotkin, Lilian I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418188/
https://ncbi.nlm.nih.gov/pubmed/28317237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12586
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