Cx43 Overexpression in Osteocytes Prevents Osteocyte Apoptosis and Preserves Cortical Bone Quality in Aging Mice

Young, skeletally mature mice lacking Cx43 in osteocytes exhibit increased osteocyte apoptosis and decreased bone strength, resembling the phenotype of old mice. Further, the expression of Cx43 in bone decreases with age, suggesting a contribution of reduced Cx43 levels to the age‐related changes in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JBMR Plus
Prif Awduron: Davis, Hannah M, Aref, Mohammad W, Aguilar‐Perez, Alexandra, Pacheco‐Costa, Rafael, Allen, Kimberly, Valdez, Sinai, Herrera, Carmen, Atkinson, Emily G, Mohammad, Arwa, Lopez, David, Harris, Marie A, Harris, Stephen E, Allen, Matthew, Bellido, Teresita, Plotkin, Lilian I
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029870/
https://ncbi.nlm.nih.gov/pubmed/29978155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10035
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