Cx43 Overexpression in Osteocytes Prevents Osteocyte Apoptosis and Preserves Cortical Bone Quality in Aging Mice

Young, skeletally mature mice lacking Cx43 in osteocytes exhibit increased osteocyte apoptosis and decreased bone strength, resembling the phenotype of old mice. Further, the expression of Cx43 in bone decreases with age, suggesting a contribution of reduced Cx43 levels to the age‐related changes in...

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Pubblicato in:JBMR Plus
Autori principali: Davis, Hannah M, Aref, Mohammad W, Aguilar‐Perez, Alexandra, Pacheco‐Costa, Rafael, Allen, Kimberly, Valdez, Sinai, Herrera, Carmen, Atkinson, Emily G, Mohammad, Arwa, Lopez, David, Harris, Marie A, Harris, Stephen E, Allen, Matthew, Bellido, Teresita, Plotkin, Lilian I
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029870/
https://ncbi.nlm.nih.gov/pubmed/29978155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10035
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