Integrated analysis of whole-genome ChIP-Seq and RNA-Seq data of primary head and neck tumor samples associates HPV integration sites with open chromatin marks

Chromatin alterations mediate mutations and gene expression changes in cancer. Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been utilized to study genome-wide chromatin structure in human cancer cell lines, yet numerous technical challenges limit comparable analyses in primary...

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Publicat a:Cancer Res
Autors principals: Kelley, Dylan Z., Flam, Emily L., Izumchenko, Evgeny, Danilova, Ludmila V., Wulf, Hildegard A., Guo, Theresa, Singman, Dzov A., Afsari, Bahman, Skaist, Alyza, Considine, Michael, Stavrovskaya, Elena, Bishop, Justin A., Westra, William H., Khan, Zubair, Koch, Wayne M., Sidransky, David, Wheelan, Sarah, Califano, Joseph A., Favorov, Alexander V., Fertig, Elana J., Gaykalova, Daria A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029614/
https://ncbi.nlm.nih.gov/pubmed/28947419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0833
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