Effects of CYP2D6 genetic polymorphisms on the efficacy and safety of fluvoxamine in patients with depressive disorder and comorbid alcohol use disorder

BACKGROUND: Fluvoxamine therapy is used for treatment of patients with depressive disorder, but it is often ineffective, and some patients suffer from dose-dependent undesirable side effects such as vertigo, headache, indigestion, xerostomia, increased anxiety, etc. CYP2D6 is involved in the biotran...

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Bibliografiske detaljer
Udgivet i:Pharmgenomics Pers Med
Main Authors: Zastrozhin, Mikhail Sergeevich, Grishina, Elena Anatolievna, Denisenko, Nataliya Petrovna, Skryabin, Valentin Yurievich, Markov, Dmitry Dmitrievich, Savchenko, Ludmila Mikhailovna, Bryun, Evgeny Alekseevich, Sychev, Dmitry Alekseevich
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029588/
https://ncbi.nlm.nih.gov/pubmed/29988737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S160763
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