Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder

BACKGROUND: Antipsychotic action of haloperidol is due to blockade of D(2) receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D(2) receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these re...

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Detalhes bibliográficos
Publicado no:Pharmgenomics Pers Med
Main Authors: Zastrozhin, Mikhail Sergeevich, Brodyansky, Vadim Markovich, Skryabin, Valentin Yurievich, Grishina, Elena Anatolievna, Ivashchenko, Dmitry Vladimirovich, Ryzhikova, Kristina Anatolievna, Savchenko, Ludmila Mikhaylovna, Kibitov, Alexander Olegovich, Bryun, Evgeny Alekseevich, Sychev, Dmitry Alekseevich
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511016/
https://ncbi.nlm.nih.gov/pubmed/28744152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S140700
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