The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction

BACKGROUND: Today, it is proved that isoenzymes CYP2D6 and CYP3A4 are involved in metabolism of haloperidol. In our previous investigation, we found a medium correlation between the efficacy and safety of haloperidol and the activity of CYP3A4 in patients with alcohol abuse. OBJECTIVE: The aim of th...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Pharmgenomics Pers Med
Main Authors: Sychev, Dmitry Alekseevich, Zastrozhin, Mikhail Sergeevich, Smirnov, Valery Valerieevich, Grishina, Elena Anatolievna, Savchenko, Ludmila Mikhailovna, Bryun, Evgeny Alekseevich
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2016
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028170/
https://ncbi.nlm.nih.gov/pubmed/27695358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S110385
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