Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder

BACKGROUND: Antipsychotic action of haloperidol is due to blockade of D(2) receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D(2) receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharmgenomics Pers Med
Prif Awduron: Zastrozhin, Mikhail Sergeevich, Brodyansky, Vadim Markovich, Skryabin, Valentin Yurievich, Grishina, Elena Anatolievna, Ivashchenko, Dmitry Vladimirovich, Ryzhikova, Kristina Anatolievna, Savchenko, Ludmila Mikhaylovna, Kibitov, Alexander Olegovich, Bryun, Evgeny Alekseevich, Sychev, Dmitry Alekseevich
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove Medical Press 2017
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511016/
https://ncbi.nlm.nih.gov/pubmed/28744152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S140700
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