TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Cellular senescence is a well-orchestrated programmed process involved in age-related pathologies, tumor suppression and embryonic development. TGF-β/Smad is one of the predominant pathways that regulate damage-induced and developmentally programmed senescence. Here we show that canonical TGF-β sign...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lyu, Guoliang, Guan, Yiting, Zhang, Chao, Zong, Le, Sun, Lei, Huang, Xiaoke, Huang, Li, Zhang, Lijun, Tian, Xiao-Li, Zhou, Zhongjun, Tao, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028646/
https://ncbi.nlm.nih.gov/pubmed/29967491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04994-z
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