T315I mutation of BCR-ABL1 into human Philadelphia chromosome-positive leukemia cell lines by homologous recombination using the CRISPR/Cas9 system

In many cancers, somatic mutations confer tumorigenesis and drug-resistance. The recently established clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system is a potentially elegant approach to functionally evaluate mutations in cancers. To reproduce mutations by homologous r...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Tamai, Minori, Inukai, Takeshi, Kojika, Satoru, Abe, Masako, Kagami, Keiko, Harama, Daisuke, Shinohara, Tamao, Watanabe, Atsushi, Oshiro, Hiroko, Akahane, Koshi, Goi, Kumiko, Sugihara, Eiji, Nakada, Shinichiro, Sugita, Kanji
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028382/
https://ncbi.nlm.nih.gov/pubmed/29967475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27767-6
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