IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform

The long-term prognosis of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) is still unsatisfactory even after the emergence of tyrosine kinase inhibitors (TKIs) against chimeric BCR-ABL, and this is associated with the high incidence of genetic alterations of Ikaros family z...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Principais autores: Harama, Daisuke, Yahata, Takashi, Kagami, Keiko, Abe, Masako, Ando, Norie, Kasai, Shin, Tamai, Minori, Akahane, Koshi, Inukai, Takeshi, Kiyokawa, Nobutaka, Ibrahim, Abd Aziz, Ando, Kiyoshi, Sugita, Kanji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195985/
https://ncbi.nlm.nih.gov/pubmed/34117218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00523-y
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