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Principles of Chromosome Architecture Revealed by Hi-C
Chromosomes are folded and compacted within interphase nuclei, but the molecular basis of this folding is poorly understood. Chromosome conformation capture methods, such as Hi-C, combine chemical cross-linking of chromatin followed by fragmentation, DNA ligation, and high-throughput DNA sequencing...
Gardado en:
| Publicado en: | Trends Biochem Sci |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6028237/ https://ncbi.nlm.nih.gov/pubmed/29685368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2018.03.006 |
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