Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs)

[Image: see text] Dinucleoside phosphoramidites containing a triazole internucleotide linkage flanked by locked nucleic acid (LNA) were synthesized and incorporated into oligonucleotides (ONs). ONs bearing both LNA and triazole at multiple sites were obtained and their biophysical properties includi...

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Bibliografiska uppgifter
I publikationen:ACS Omega
Huvudupphovsmän: Kumar, Pawan, Truong, Lynda, Baker, Ysobel Ruth, El-Sagheer, Afaf Helmy, Brown, Tom
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2018
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028152/
https://ncbi.nlm.nih.gov/pubmed/29978149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01086
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