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Inhibiting Gene Expression with Locked Nucleic Acids (LNAs) that Target Chromosomal DNA
Oligonucleotides containing locked nucleic acid bases (LNAs) have increased affinity for complementary DNA sequences. We hypothesized that enhanced affinity might allow LNAs to recognize chromosomal DNA inside human cells and inhibit gene expression. To test this hypothesis, we synthesized antigene...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527755/ https://ncbi.nlm.nih.gov/pubmed/17536839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700227g |
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