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Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs)

[Image: see text] Dinucleoside phosphoramidites containing a triazole internucleotide linkage flanked by locked nucleic acid (LNA) were synthesized and incorporated into oligonucleotides (ONs). ONs bearing both LNA and triazole at multiple sites were obtained and their biophysical properties includi...

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Publicat a:ACS Omega
Autors principals: Kumar, Pawan, Truong, Lynda, Baker, Ysobel Ruth, El-Sagheer, Afaf Helmy, Brown, Tom
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028152/
https://ncbi.nlm.nih.gov/pubmed/29978149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01086
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