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Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs)

[Image: see text] Dinucleoside phosphoramidites containing a triazole internucleotide linkage flanked by locked nucleic acid (LNA) were synthesized and incorporated into oligonucleotides (ONs). ONs bearing both LNA and triazole at multiple sites were obtained and their biophysical properties includi...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:ACS Omega
Päätekijät: Kumar, Pawan, Truong, Lynda, Baker, Ysobel Ruth, El-Sagheer, Afaf Helmy, Brown, Tom
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2018
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028152/
https://ncbi.nlm.nih.gov/pubmed/29978149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01086
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