Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

Cyclic oligonucleotides are valuable targets with a broad range of potential applications spanning molecular biology and nanotechnology. Of particular importance is their role as templates in the rolling circle amplification (RCA) reaction. We describe three different chemical cyclisation methods fo...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Chen, Jinfeng, Baker, Ysobel R., Brown, Asha, El-Sagheer, Afaf H., Brown, Tom
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238721/
https://ncbi.nlm.nih.gov/pubmed/30542561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc02952k
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