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AKT1 Activation is Obligatory for Spontaneous BCC Tumor Growth in a Murine Model That Mimics Some Features of Basal Cell Nevus Syndrome
Patients with basal cell nevus syndrome (BCNS), also known as Gorlin syndrome, develop numerous basal cell carcinomas (BCCs) due to germline mutations in the tumor suppressor PTCH1 and aberrant activation of Hedgehog (Hh) signaling. Therapies targeted at components of the Hh pathway, including the s...
שמור ב:
| הוצא לאור ב: | Cancer Prev Res (Phila) |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6028004/ https://ncbi.nlm.nih.gov/pubmed/27388747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-16-0066 |
| תגים: |
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