AKT1 Activation is Obligatory for Spontaneous BCC Tumor Growth in a Murine Model That Mimics Some Features of Basal Cell Nevus Syndrome

Patients with basal cell nevus syndrome (BCNS), also known as Gorlin syndrome, develop numerous basal cell carcinomas (BCCs) due to germline mutations in the tumor suppressor PTCH1 and aberrant activation of Hedgehog (Hh) signaling. Therapies targeted at components of the Hh pathway, including the s...

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發表在:Cancer Prev Res (Phila)
Main Authors: Kim, Arianna L., Back, Jung Ho, Zhu, Yucui, Tang, Xiuwei, Yardley, Nathan P., Kim, Katherine J., Athar, Mohammad, Bickers, David R.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028004/
https://ncbi.nlm.nih.gov/pubmed/27388747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-16-0066
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