The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

Biochemical, structural, and cellular studies reveal Jumonji-C (JmjC) domain-containing 7 (JMJD7) as a 2-oxoglutarate (2OG)-dependent oxygenase catalyzing a previously unreported type of post-translational modification, (3S)-lysyl hydroxylation. Crystallographic analyses reveal JMJD7 as more closely...

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Publicado no:Nat Chem Biol
Main Authors: Markolovic, Suzana, Zhuang, Qinqin, Wilkins, Sarah E, Eaton, Charlotte D, Abboud, Martine I, Katz, Maximiliano J, McNeil, Helen E, Leśniak, Robert K, Hall, Charlotte, Struwe, Weston B, Konietzny, Rebecca, Davis, Simon, Yang, Ming, Ge, Wei, Benesch, Justin LP, Kessler, Benedikt M, Ratcliffe, Peter J, Cockman, Matthew E, Fischer, Roman, Wappner, Pablo, Chowdhury, Rasheduzzaman, Coleman, Mathew L, Schofield, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027965/
https://ncbi.nlm.nih.gov/pubmed/29915238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0071-y
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