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Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)

Lysosomal phospholipase A2 (LPLA(2)) is characterized by broad substrate recognition, peak activity at acidic pH, and the transacylation of lipophilic alcohols, especially N-acetyl-sphingosine. Prior structural analysis of LPLA(2) revealed the presence of an atypical acidic residue, Asp13, in the ot...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Hinkovska-Galcheva, Vania, Kelly, Robert, Manthei, Kelly A., Bouley, Renee, Yuan, Wenmin, Schwendeman, Anna, Tesmer, John J. G., Shayman, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027918/
https://ncbi.nlm.nih.gov/pubmed/29724779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M084012
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