Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint

BACKGROUND: Targeting poly ADP-ribose polymerase (PARP) has been recently identified as a promising option against gastric cancer (GC). However, PARP inhibitors alone achieve limited efficacy. Combination strategies, especially with homologous recombination (HR) impairment, are of great hope to opti...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Lin, Xiaoting, Chen, Dongshao, Zhang, Cheng, Zhang, Xiaotian, Li, Zhongwu, Dong, Bin, Gao, Jing, Shen, Lin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027790/
https://ncbi.nlm.nih.gov/pubmed/29954437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0790-7
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