Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

Parkinson disease (PD) is the second most common neurodegenerative disorder and the leading neurodegenerative cause of motor disability. Pathologic accumulation of aggregated alpha synuclein (AS) protein in brain, and imbalance in the nigrostriatal system due to the loss of dopaminergic neurons in t...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Jan, Asad, Jansonius, Brandon, Delaidelli, Alberto, Bhanshali, Forum, An, Yi Andy, Ferreira, Nelson, Smits, Lisa M., Negri, Gian Luca, Schwamborn, Jens C., Jensen, Poul H., Mackenzie, Ian R., Taubert, Stefan, Sorensen, Poul H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027557/
https://ncbi.nlm.nih.gov/pubmed/29961428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0554-9
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