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α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicate perturbations in the tissue homeostatic mechanis...
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| Veröffentlicht in: | Acta Neuropathol Commun |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8183088/ https://ncbi.nlm.nih.gov/pubmed/34092244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01209-3 |
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