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MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation

MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN amplification in childhood neuroblastoma (NB) is associated with aggressive disease and high mortality. Novel and effective therapeutic strategies are therefore urgently needed for...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cell Death Differ
Main Authors: Delaidelli, Alberto, Negri, Gian Luca, Jan, Asad, Jansonius, Brandon, El-Naggar, Amal, Lim, Jonathan K M, Khan, Debjit, Zarni Oo, Htoo, Carnie, Christopher J, Remke, Marc, Maris, John M, Leprivier, Gabriel, Sorensen, Poul H
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563988/
https://ncbi.nlm.nih.gov/pubmed/28574509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.79
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