MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation

MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN amplification in childhood neuroblastoma (NB) is associated with aggressive disease and high mortality. Novel and effective therapeutic strategies are therefore urgently needed for...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Delaidelli, Alberto, Negri, Gian Luca, Jan, Asad, Jansonius, Brandon, El-Naggar, Amal, Lim, Jonathan K M, Khan, Debjit, Zarni Oo, Htoo, Carnie, Christopher J, Remke, Marc, Maris, John M, Leprivier, Gabriel, Sorensen, Poul H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563988/
https://ncbi.nlm.nih.gov/pubmed/28574509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.79
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