MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation

MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN amplification in childhood neuroblastoma (NB) is associated with aggressive disease and high mortality. Novel and effective therapeutic strategies are therefore urgently needed for...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Delaidelli, Alberto, Negri, Gian Luca, Jan, Asad, Jansonius, Brandon, El-Naggar, Amal, Lim, Jonathan K M, Khan, Debjit, Zarni Oo, Htoo, Carnie, Christopher J, Remke, Marc, Maris, John M, Leprivier, Gabriel, Sorensen, Poul H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563988/
https://ncbi.nlm.nih.gov/pubmed/28574509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.79
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