CBMT-05. ROLE OF THE let7-eEF2K AXIS IN MYC-DRIVEN MEDULLOBLASTOMA ADAPTATION TO NUTRIENT DEPRIVATION

BACKGROUND/OBJECTIVES: MYC amplification in medulloblastoma (MB) determines highly aggressive disease, underscoring an urgent need for novel therapies. Let-7 microRNAs (miRNAs) inhibit tumor progression and regulate metabolism by degrading several mRNAs, including MYC. Let-7 miRNAs are frequently re...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Delaidelli, Alberto, Luca Negri, Gian, Sidhu, Simran, Remke, Marc, Pfister, Stefan, Taylor, Michael, Leprivier, Gabriel, Kool, Marcel, Sorensen, Poul
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216938/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.124
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