Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-dri...

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Publicado en:Nat Commun
Main Authors: He, Hongbin, Jiang, Hua, Chen, Yun, Ye, Jin, Wang, Aoli, Wang, Chao, Liu, Qingsong, Liang, Gaolin, Deng, Xianming, Jiang, Wei, Zhou, Rongbin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026158/
https://ncbi.nlm.nih.gov/pubmed/29959312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04947-6
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