Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy

Myotonic dystrophy type 2 (DM2) is a neuromuscular disease caused by an expansion of intronic CCTG repeats in the CNBP gene, which encodes a protein regulating translation and transcription. To better understand the role of cellular nucleic acid binding protein (CNBP) in DM2 pathology, we examined s...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Wei, Christina, Stock, Lauren, Schneider-Gold, Christiane, Sommer, Claudia, Timchenko, Nikolai A., Timchenko, Lubov
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6024164/
https://ncbi.nlm.nih.gov/pubmed/29735719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00649-17
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