NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment

Natural killer (NK) cell-based immunotherapy is a promising therapy for cancer patients. Inhibitory killer immunoglobulin-like receptors (KIRs) and NKG2A are required for NK cell licensing, but can also inhibit NK cell effector function. Upon reconstitution in a stem cell transplantation setting or...

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Publicado en:Front Immunol
Main Authors: Mahaweni, Niken M., Ehlers, Femke A. I., Sarkar, Subhashis, Janssen, Johanna W. H., Tilanus, Marcel G. J., Bos, Gerard M. J., Wieten, Lotte
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023990/
https://ncbi.nlm.nih.gov/pubmed/29988376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01415
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