Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics

OBJECTIVE—: Platelet activation after stimulation of PAR (protease-activated receptor) 4 is heightened in platelets from blacks compared with those from whites. The difference in PAR4 signaling by race is partially explained by a single-nucleotide variant in PAR4 encoding for either an alanine or th...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Tourdot, Benjamin E., Stoveken, Hannah, Trumbo, Derek, Yeung, Jennifer, Kanthi, Yogendra, Edelstein, Leonard C., Bray, Paul F., Tall, Gregory G., Holinstat, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
Assuntos:
Translational Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023764/
https://ncbi.nlm.nih.gov/pubmed/29748334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311112
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