Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race

Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. Recently, we reported 3.7-fold increased PAR4-mediated aggregation kinetics in platelets from black subjects compared with white subjects. We now show that platelets from blacks (n = 70) express 14% more PAR4...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Edelstein, Leonard C., Simon, Lukas M., Lindsay, Cory R., Kong, Xianguo, Teruel-Montoya, Raúl, Tourdot, Benjamin E., Chen, Edward S., Ma, Lin, Coughlin, Shaun, Nieman, Marvin, Holinstat, Michael, Shaw, Chad A., Bray, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246040/
https://ncbi.nlm.nih.gov/pubmed/25293779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-572479
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