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Establishing the Transient Mass Balance of Thrombosis: From Tissue Factor to Thrombin to Fibrin Under Venous Flow

OBJECTIVE—: We investigated the coregulation of thrombin and fibrin as blood flows over a procoagulant surface. APPROACH AND RESULTS—: Using microfluidic perfusion of factor XIIa-inhibited human whole blood (200 s(−1) wall shear rate) over a 250-μm long patch of collagen/TF (tissue factor; ≈1 molecu...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Zhu, Shu, Chen, Jason, Diamond, Scott L.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023760/
https://ncbi.nlm.nih.gov/pubmed/29724819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.310906
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