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LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies

BACKGROUND: To date, genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants among a variety of traits/diseases, shedding light on the genetic architecture of complex disease. The polygenicity of complex diseases is a widely accepted phenomenon throu...

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Библиографические подробности
Опубликовано в: :BMC Genomics
Главные авторы: Yang, Yi, Dai, Mingwei, Huang, Jian, Lin, Xinyi, Yang, Can, Chen, Min, Liu, Jin
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022345/
https://ncbi.nlm.nih.gov/pubmed/29954342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-4851-2
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