The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage

Clerocidin, a diterpenoid with antibacterial and antitumor activity, stimulates in vitro DNA cleavage mediated by mammalian and bacterial topoisomerase (topo) II. Different from the classical topoisomerase poisons, clerocidin-stimulated breaks at guanines immediately preceding the sites of DNA cleav...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Gatto, Barbara, Richter, Sara, Moro, Stefano, Capranico, Giovanni, Palumbo, Manlio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60217/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11600711/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.20.4224
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