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Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm

Polymyxin B is used as an antibiotic of last resort for patients with multidrug-resistant Gram-negative bacterial infections; however, it carries a significant risk of nephrotoxicity. Herein we present a polymyxin B therapeutic window based on target area under the concentration-time curve (AUC) val...

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書目詳細資料
發表在:Antimicrob Agents Chemother
Main Authors: Lakota, Elizabeth A., Landersdorfer, Cornelia B., Nation, Roger L., Li, Jian, Kaye, Keith S., Rao, Gauri G., Forrest, Alan
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021635/
https://ncbi.nlm.nih.gov/pubmed/29760144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00483-18
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