Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse

INTRODUCTION: Translational inhibition of amyloid precursor protein (APP) by Posiphen has been shown to reduce APP and its fragments in cell culture, animal models, and mildly cognitively impaired patients, making it a promising drug candidate for the treatment of Alzheimer's disease. METHODS:...

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Veröffentlicht in:Alzheimers Dement (N Y)
Hauptverfasser: Teich, Andrew F., Sharma, Ekta, Barnwell, Eliza, Zhang, Hong, Staniszewski, Agnieszka, Utsuki, Tadanobu, Padmaraju, Vasudevaraju, Mazell, Cheryl, Tzekou, Apostolia, Sambamurti, Kumar, Arancio, Ottavio, Maccecchini, Maria L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021259/
https://ncbi.nlm.nih.gov/pubmed/29955650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2017.12.001
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