Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles

Dysfunctional endothelial cells contribute to the pathophysiology of many diseases, including vascular disease, stroke, hypertension, atherosclerosis, organ failure, diabetes, retinopathy, and cancer. Toward the goal of creating a new RNA-based therapy to correct aberrant endothelial cell gene expre...

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Vydáno v:Sci Adv
Hlavní autoři: Khan, Omar F., Kowalski, Piotr S., Doloff, Joshua C., Tsosie, Jonathan K., Bakthavatchalu, Vasudevan, Winn, Caroline Bodi, Haupt, Jennifer, Jamiel, Morgan, Langer, Robert, Anderson, Daniel G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021147/
https://ncbi.nlm.nih.gov/pubmed/29963629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar8409
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