Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancreatic ductal adenocarcinoma (PDAC) and identify a phenomenon...

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Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Conway, James R.W., Warren, Sean C., Herrmann, David, Murphy, Kendelle J., Cazet, Aurélie S., Vennin, Claire, Shearer, Robert F., Killen, Monica J., Magenau, Astrid, Mélénec, Pauline, Pinese, Mark, Nobis, Max, Zaratzian, Anaiis, Boulghourjian, Alice, Da Silva, Andrew M., del Monte-Nieto, Gonzalo, Adam, Arne S.A., Harvey, Richard P., Haigh, Jody J., Wang, Yingxiao, Croucher, David R., Sansom, Owen J., Pajic, Marina, Caldon, C. Elizabeth, Morton, Jennifer P., Timpson, Paul
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019737/
https://ncbi.nlm.nih.gov/pubmed/29898401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.038
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