Potential role for histone deacetylation in chronic diazepam‐induced downregulation of α1‐GABA(A) receptor subunit expression

Corroborating evidence indicate that the downregulation of GABA(A) receptor subunit expression may underlie tolerance to the anticonvulsant and anxiolytic actions of benzodiazepine (BZ) ligands that act as full allosteric modulators (FAMs) of GABA actions at a variety of GABA(A) receptor subtypes. W...

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Dettagli Bibliografici
Pubblicato in:Pharmacol Res Perspect
Autori principali: Auta, James, Gatta, Eleonora, Davis, John M., Pandey, Subhash C., Guidotti, Alessandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019704/
https://ncbi.nlm.nih.gov/pubmed/29951207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.416
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