GABA(A) Receptor α Subunits Differentially Contribute to Diazepam Tolerance after Chronic Treatment

BACKGROUND: Within the GABA(A)-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can be ascribed to certain GABA(A)-receptor subtypes. METHODS: We investigated tolerance to acute anxiolytic, hypothermic and sedative effects...

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Detalhes bibliográficos
Main Authors: Vinkers, Christiaan H., van Oorschot, Ruud, Nielsen, Elsebet Ø., Cook, James M., Hansen, Henrik H., Groenink, Lucianne, Olivier, Berend, Mirza, Naheed R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418228/
https://ncbi.nlm.nih.gov/pubmed/22912786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043054
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