UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis

Genomic damage can feature DNA-protein crosslinks whereby their acute accumulation is utilized to treat cancer and progressive accumulation causes neurodegeneration. This is typified by tyrosyl DNA phosphodiesterase 1 (TDP1), which repairs topoisomerase-mediated chromosomal breaks. Although TDP1 lev...

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Publicat a:Cell Rep
Autors principals: Liao, Chunyan, Beveridge, Ryan, Hudson, Jessica J.R., Parker, Jacob D., Chiang, Shih-Chieh, Ray, Swagat, Ashour, Mohamed E., Sudbery, Ian, Dickman, Mark J., El-Khamisy, Sherif F.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019701/
https://ncbi.nlm.nih.gov/pubmed/29898404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.033
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