Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism

Mutations in the SHANK family of genes have been consistently identified in genetic and genomic screens of autism spectrum disorder (ASD). The functional overlap of SHANK with several other ASD-associated genes suggests synaptic dysfunction as a convergent mechanism of pathophysiology in ASD. Althou...

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Detaylı Bibliyografya
Yayımlandı:Front Mol Neurosci
Asıl Yazarlar: Modi, Meera E., Brooks, Julie M., Guilmette, Edward R., Beyna, Mercedes, Graf, Radka, Reim, Dominik, Schmeisser, Michael J., Boeckers, Tobias M., O’Donnell, Patricio, Buhl, Derek L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018
Konular:
Neuroscience
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018399/
https://ncbi.nlm.nih.gov/pubmed/29970986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00107
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