Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism

Mutations in the SHANK family of genes have been consistently identified in genetic and genomic screens of autism spectrum disorder (ASD). The functional overlap of SHANK with several other ASD-associated genes suggests synaptic dysfunction as a convergent mechanism of pathophysiology in ASD. Althou...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Modi, Meera E., Brooks, Julie M., Guilmette, Edward R., Beyna, Mercedes, Graf, Radka, Reim, Dominik, Schmeisser, Michael J., Boeckers, Tobias M., O’Donnell, Patricio, Buhl, Derek L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018399/
https://ncbi.nlm.nih.gov/pubmed/29970986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00107
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