Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

SHANK3 (also called PROSAP2) genetic haploinsufficiency is thought to be the major cause of neuropsychiatric symptoms in Phelan-McDermid syndrome (PMS). PMS is a rare genetic disorder that causes a severe form of intellectual disability (ID), expressive language delays and other autistic features. F...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Psychiatry
Main Authors: Vicidomini, Cinzia, Ponzoni, Luisa, Lim, Dmitry, Schmeisser, Michael, Reim, Dominik, Morello, Noemi, Orelanna, Daniel, Tozzi, Alessandro, Durante, Valentina, Scalmani, Paolo, Mantegazza, Massimo, Genazzani, Armando A., Giustetto, Maurizio, Sala, Mariaelvina, Calabresi, Paolo, Boeckers, Tobias M., Sala, Carlo, Verpelli, Chiara
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014121/
https://ncbi.nlm.nih.gov/pubmed/27021819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.30
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki