Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

SHANK3 (also called PROSAP2) genetic haploinsufficiency is thought to be the major cause of neuropsychiatric symptoms in Phelan-McDermid syndrome (PMS). PMS is a rare genetic disorder that causes a severe form of intellectual disability (ID), expressive language delays and other autistic features. F...

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Udgivet i:Mol Psychiatry
Main Authors: Vicidomini, Cinzia, Ponzoni, Luisa, Lim, Dmitry, Schmeisser, Michael, Reim, Dominik, Morello, Noemi, Orelanna, Daniel, Tozzi, Alessandro, Durante, Valentina, Scalmani, Paolo, Mantegazza, Massimo, Genazzani, Armando A., Giustetto, Maurizio, Sala, Mariaelvina, Calabresi, Paolo, Boeckers, Tobias M., Sala, Carlo, Verpelli, Chiara
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014121/
https://ncbi.nlm.nih.gov/pubmed/27021819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.30
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